Clinical and translational science

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簡介(Book Description from Google)：
Clinical and translational science are fields devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. This book is designed as the most authoritative and up-to-date resource for the broad range of investigators in various medical specialties taking on the challenge of clinical and translational science. Prepared with an international perspective, Clinical and Translational Science begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, legal, social, and ethical issues of clinical research are discussed concluding with a discussion of future prospects to provide readers with a comprehensive view of this developing area of science. * Discusses practical biological, physiological, cellular, and therapeutic applications for one of the fastest growing fields in private practice and academic medicine * Includes contributions from international leaders providing insight into background and future understanding for clinical and translational science * Presents the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

Customer Reviews from Amazon:

Finally, a complete text for clinical trials
All medical fellows and especially PhD post-docs engaged in biological research should have this text. Whether or not, they think that their research will lead to a human clinical trial, this text describes in excellent detail how to think about tasks requisite to human experimentation. There is no other text which includes the arcana of human trials from designing experiements, to regulations, and even what documentation is needed to move a therapeutic regimen to market. While one would expect such a text to describe experimental design methods such as pharmacokinetics and sample size calculations, this text explores such topics as how to work with venture capitalists compared to private equity firms and philanthropic organizations. The book is lucidly written with great illustrations accompanying the text. Even the paper stock is pleasant to handle, which I find a rarity anymore. My only complaint, and it is minor, is that the order of the chapters does not seem to follow a logical sequence. Everything is there, but as I read the book from the beginning, I found chapters in the middle which I thought should have been in the earlier sections. While it is a minor complaint, I would suggest that a fellow should seek the advice of her specialty chief about which chapters to read first. The book could easily serve as a year-long text for a course in theory and conduct of clinical trials. From my 20+ years of experience as a principal investigator and executive of a clinical trials firm, I would require this text for everyone participating in human trials. I only wish I had this text 30 years ago when I was a fellow, it would have saved me a lot of time wandering in the confusing miasma of science and regulations conducting clinical trials.

A great introduction to this field
I really like this book because it's the only one I've found that really surveys and explains what clinical and translational science is all about. This "new discipline" resembles what used to be called medical research in human beings, but now it has become much broader, in order to overcome two gaps (T1 and T2) that stood in the way of progress. Clinical and Translational Science reaches all the way from the basic science laboratory, across the "Translational 1" (T1) gap to testing in patients and then across the "Translational 2" (T2) gap to introduction into public health and community engagement. The book provides an excellent introduction to the essential disciplines that enable the student to come away with a very complete picture of how medical research happens ... what is required to make discoveries, how to carry them into clinical trials, how to navigate the regulatory and bioethical environment, and how to take discoveries into the community. Everyone involved in the medical discovery process, clinical research, the drug industry, or public health will need to have this book. If you're interested in a career in medical research, I think this is the place to start.

Outstanding Contribution
An outstanding primer on clinical and translational research by renowned experts in the field. Comprehensive and well written, this book is a much needed addition to the literature on this timely subject. Anne Klibanski, M.D.

書名 Clinical and translational science
著者 edited by David Robertson, Gordon H. Williams
索書號 W20.5/C64113/2009
出版者 Elsevier/Academic Press
ISBN 9780123736390(hbk.)
出版年 2009